Effect of reoxygenation on the electrical stability of the rat heart in vivo: a chronobiological study.

Effect of antihypertensive agents - captopril and nifedipine - on the functional properties of rat heart mitochondria

Objective(s): Investigation of acute effect on cellular bioenergetics provides the opportunity to characterize the possible adverse effects of drugs more comprehensively. This study aimed to investigate the changes in biochemical and biophysical properties of heart mitochondria induced by captopril and nifedipine antihypertensive treatment. Materials and Methods: Male, 12-week-old Wistar rats i...

Chronobiological Aspects of Impact of Apnoic Episode and Reoxygenation on the Electrical Myocardial Properties and Autonomic Nervous System Activity in Wistar Rats

Hypoxia-reoxygenation induced necroptosis in cultured rat renal tubular epithelial cell line

Objective(s): The aim of this study is to explore the potential role of hypoxia/reoxygenation in necroptosis in cultured rat renal tubular epithelial cell line NRK-52E, and further to investigate its possible mechanisms.Materials and Methods: Cells were cultured under different hypoxia-reoxygenation conditions                        in vitro. MTT assay was used to measure the cell proliferation...

The effect of crocin (a derivative of Crocus sativus L.) on neural development and regeneration of rat: in vivo and in vitro study

In this study, the effect of crocin, a substance found in Crocus sativus L. stigmata on nervous system development and regeneration was investigated. Crocin is a glycosyl ester of the polyene dicarboxylic acid crocetin and is one of the few families of carotenoids found in nature, which are freely soluble in water. In the first experiment, the effect of crocin (30 microM, 60 microM and 120 micr...

Histopathological evaluation of the role of negative electrical charge on renal ischemia/reperfusion injuries on brain and heart tissues in rat

This study was performed to evaluate the role of electroacupuncture on kidney 1 (Ki1) acupoint to prevent the heart and brain injury following ischemia/reperfusion of both kidneys. 24 Sprague Dawley rats were randomly assigned into four equal groups. In the treatment 1 group, following anesthesia, acupuncture needles were inserted on Ki1 on the palm of both hindlimbs and connected to electroacu...